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Figure 1

From: Characterization of experimental diabetic neuropathy using multicontrast magnetic resonance neurography at ultra high field strength

Figure 1

Behavioural phenotyping of STZ-induced diabetic mice. (a–c) Thermal nociception was tested measuring the behavioural latency [s] using the three different assays ‘Hotplate’, ‘Tailflick’ and ‘Hargreaves’. Significant differences between STZ-induced mice and controls were noted in the ‘Hotplate’ and ‘Hargreaves’. Group data provided as group mean ± s.d. *=p < 0.05, **=p < 0.01, n.s. = nonsignificant, unpaired two-sided t-test. N = 10 vs. 13 mice for ‘Hotplate’ and ‘Tailflick’ assays, n = 20 vs. 26 limbs for ‘Hargreaves’ assay. d-f) Significant correlation was noted for all of the behavioural assays and HbA1c values (Hotplate: r = 0.59, p = 0.003; Tailflick: r = 0.59, p = 0.003; Hargreaves: r = 0.43, p = 0.04). Linear regression graphs shown (n = 23 mice).

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