Figure 6 | Scientific Reports

Figure 6

From: Characterization of experimental diabetic neuropathy using multicontrast magnetic resonance neurography at ultra high field strength

Figure 6The alternative text for this image may have been generated using AI.

Light microscopic analysis of the sciatic nerves from STZ-diabetic mice. (a) Gross anatomical findings of Toluidine blue stained semithin sciatic nerve sections from control and STZ animals using light microscopy (LM). Inset shows a representative region in x2-magnification. (b–d) Quantitative findings of the control (Ctrl) and the STZ groups (n = 3 each) comparing the three parameters b) ‘axon density’, (c) ‘myelin density’ (i.e. the myelin fraction within the nerve cross-sectional area (CSA)) and (d) ‘average myelination’ (i.e. myelin area per axon); n.s. = nonsignificant, unpaired two-sided t-test. (e) Histogram plot showing the frequency distribution of the equivalent axon radius within the population of all myelinated axons inside the nerve CSA. Each bar indicates group mean ± s.d. (n = 3 each). *p < 0.05, **p < 0.01, ***p < 0.001, unpaired two-sided t-test.

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