Table 1 General characteristics of PI3K pan-inhibitors in mouse models.

Campa¹¹

2018

OVA induced C57BL/6J and BALB/c mice

BALF

10

6

CL27c

2 mg/mL

E, N, L, M, T, 5, 13

Wagh¹²

2017

OVA induced BALB/c mice

BALF

6

6

INK654

30 mg/kg

E, N, L, M, T, α, 2, 5, 6, γ

Huang¹³

2017

IL-25 induced BALB/c mice

BALF

5

5

LY294002

80 μg/50 μL

E, N, L, T, α, 5, 6, 13, Eo, 1β, β, V

Oikawa¹⁴

2016

OVA induced C57BL6 mice

BALF (cytokines), blood (cell counts)

6

6

ZSTK474

30 mg/kg

E, T, 4, 5, 13, β

Saw¹⁵

2016

Cockroach induced BALB/c mice

BALF (cell counts, cytokines), blood (I)

6

6

LY294002

3 mg/kg

E, N, T, 4, 5, 13, 10, 12, I

Yao¹⁶

2015

TDI induced BALB/c mice

BALF (cell counts), blood (I)

8

8

LY294002

1.5 mg/kg

E, N, L, M, T, I

Liang¹⁷

2015

TDI induced BALB/c mice

BALF (cell counts,4), blood (I)

7

7

LY294002

1.5 mg/kg

E, N, L, M, T, I, 4

Choi¹⁸

2013

OVA induced BALB/c mice

BALF

5

5

LY294002

1.5 mg/kg

E, N, L, M, T, 4, 5, 13, α, 1β, Eo

Xia¹⁹

2012

OVA induced rat

BALF

8

8

Wortmannin

15 μg/kg

E, N, L, M, 4, γ

Duan²⁰

2005

OVA induced BALB/c mice

BALF

6

6

LY294002

3.75 mg/kg

E, N, L, M, T, 4, 5, 13, Eo, γ

Kwak²¹

2003

OVA induced BALB/c mice

BALF

6

6

Wortmannin

100 μg/kg

E, N, L, M, T, 4, 5