Table 2 General characteristics of PI3K-δ inhibitors in mouse models.

From: Roles of PI3K pan-inhibitors and PI3K-δ inhibitors in allergic lung inflammation: a systematic review and meta-analysis

Author

Publication year

Model

Fluid or blood

N Exp

N Con

Drug

Dose

Primary outcomes

Lee22

2016

Fungus induced C57BL/6 mice

BALF, blood (I)

5

5

IC87114

0.1 mg/kg

E, N, L, T, 4, 5, 13, I

Collmann23

2013

p110dDA mice

BMMC, HUVEC

3

3

IC87114

—

6, α

Kang24

2012

Cockroach induced BALB/c mice

BALF, lung tissue

14

12

IC87114

10 μg

E, N, L, T, 4, 5, 13, Eo

Lee25

2006

OVA induced BALB/c mice

BALF

8

8

IC87114

0.1, 1 mg/kg

E, N, L, T, V

Lee26(FASEB)

2006

OVA induced BALB/c mice

BALF, blood (I)

6

6

IC87114

0.1, 1 mg/kg

E, N, L, M, T, 4, 5, 13, I, α, Eo, 1β

Park27

2010

OVA induced C57BL/6 mice,

BALF

7

7

IC87114

0.1, 1 mg/kg

E, N, L, T

  1. Abbreviations: Exp: experimental; Con: control; BALF: bronchoalveolar lavage fluid; OVA: ovalbumin; BMMC: bone marrow mononuclear cells; HUVEC: human umbilical vein endothelial cells; E: eosinophils; N: neutrophils; L: lymphocytes; M: macrophages; T: total cell counts; I: IgE; α: TNF-α; 2: IL-2; 4: IL-4; 5: IL-5; 6: IL-6; 10: IL-10; 12: IL-12; 13: IL-13; γ: IFN-γ; β: TGF-β; 1β: IL-1β; Eo: eotaxin; V, VEGF.
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