Figure 5
From: Cell-specific metabolomic responses to injury: novel insights into blood-brain barrier modulation
Glycogenolysis and glycolysis support AC and EC energy generation differently. AC and EC levels of metabolites that participate in glycogen synthesis; glucose (a), UDP-glucose (b) and glycogen (c). Hatched histograms highlight metabolites detected by independent and specific quantitative biochemical analysis. The levels of pyruvate (d) and abundance of metabolites in TCA cycle (e,f). Levels of NAD + a co-factor of glycolysis (g), glutamate (h) and glutamine (i), other carbon sources of the TCA cycle. AC and EC were exposed to normoxia (NX), hypoxia (HX) and near anoxia (AX) without glucose (-Glc) for 24 h. All conditions compared to their own control conditions (NX + Glc). N = 4. *P < 0.05, **P < 0.01, ***P < 0.001; 1-way ANOVA. N.D. not determined. Data presented as mean ± SD of n = 4.
