Table 1 Different diindolylmethane-based-thiadiazole analogs and their urease activity (1–18).
From: Synthesis of diindolylmethane (DIM) bearing thiadiazole derivatives as a potent urease inhibitor
S.No. | R | IC50 ± SEMa | S.No. | R | IC50 ± SEMa |
|---|---|---|---|---|---|
1 |
| 13.20 ± 0.30 | 10 |
| 1.6 ± 0.01 |
2 |
| 1.80 ± 0.01 | 11 |
| 33.20 ± 1.20 |
3 |
| 1.10 ± 0.01 | 12 |
| 8.50 ± 0.30 |
4 |
| 2.20 ± 0.10 | 13 |
| 5.10 ± 0.10 |
5 |
| 7.30 ± 0.10 | 14 |
| 19.80 ± 0.80 |
6 |
| 0.70 ± 0.01 | 15 |
| 3.90 ± 0.10 |
7 |
| 2.30 ± 0.10 | 16 |
| 23.80 ± 1.00 |
8 |
| 0.50 ± 0.01 | 17 |
| 28.60 ± 1.20 |
9 |
| 1.10 ± 0.01 | 18 |
| 20.40 ± 1.20 |
Standard Drug | Thiourea | 21.60 ± 0.70 | |||
