Figure 4

Time courses of integral calcium release fluxes (CRF). Top – Noisy lines - typical time courses of the integral calcium release flux in CTR (left) and IMY (right) myocytes; solid lines - the best-fitted curves of integral CRF (Eq. 2). Dashed and dotted lines – the early and the late components of the best fit curves, respectively. Bottom - The simulated average integral calcium release flux (Eq. 2) with parameters from Table 3. Solid line - the average integral CRF (R = R₁ + R₂). Dashed and dotted lines - the average early (R₁) and late component (R₂), respectively.