Table 6 Matrix effect (ME) data for colistin A, colistin B and IS in six different rat plasma using LC-MS/MS method.

From: Quantification of Colistin in Plasma by Liquid Chromatography-Tandem Mass Spectrometry: Application to a Pharmacokinetic Study

Nominal concentration (ng/ml)

Colistin A

 

Matrix effect (%)

234

95.19

546

98.97

1170

103.22

2730

102.78

Nominal concentration (ng/mL)

Colistin B

 

Matrix effect (%)

1059

105.42

2471

104.75

5295

103.45

12355

103.63

Nominal concentration (µg/mL)

IS

 

Matrix effect (%)

500

95.19

500

105.35

500

105.86

500

105.48

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