Table 7 Mean (± S.D) pharmacokinetic parameters of colistin in rats (n = 8).

From: Quantification of Colistin in Plasma by Liquid Chromatography-Tandem Mass Spectrometry: Application to a Pharmacokinetic Study

Pharmacokinetic Parameter

Mean ± S.D.

t1/2 (min)

64.50 ± 36.30

AUC0-∞ (µg.min/ml)

631.37 ± 246.71

Vd (L/Kg)

2.45 ± 1.29

CL (mL/min/Kg)

25.53 ± 10.60

  1. t1/2: half life.
  2. AUC0-∞: Area under the plasma concentration-time curve.
  3. Vd: Volume of distribution.
  4. CL: Total body clearance.
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