Figure 4
From: Co-chaperones DNAJA1 and DNAJB6 are critical for regulation of polyglutamine aggregation
Rescue experiments displaying that restoring expression of the individual proteins in cell with KO of DNAJB6 (A) or DNAJA1 (B), caused the level of polyQ74htt aggregation to return to the levels of parental control cells. Verification of re-introduction of DNAJB6 (C) or DNAJA1 (D) into DNAJB6 KO or DNAJA1 KO HEK293 cells respectively. Emp: Empty vector control. *p < 0.05, **p < 0.01, analysed by one-way ANOVA. (n = 3).
