Figure 5

EHD2 expression levels predict chemotherapy efficacy in TNBC. (a) Analysis of MFS in 236 patients treated with chemotherapy was determined by the interval between initial diagnosis and detection of the first metastasis. Survival distributions were plotted using the Kaplan–Meier method, and the significance of the difference was ascertained with the log-rank test using optimal cutoffs (0.385). (b) MFS of 61 patients with TNBC treated with chemotherapy was determined by the interval between initial diagnosis and detection of the first metastasis. Survival distributions were plotted using the Kaplan–Meier method, and the significance of the difference was ascertained with the log-rank test using optimal cutoffs (0.3955). Patients with high EHD2 mRNA expression had a significantly poorer prognosis compared to patients with reduced EHD2 mRNA expression (P = 0.027). (c) Multivariate COX analysis of MFS for EHD2 mRNA expression in the series of 61 patients with TNBC treated with chemotherapy.