Figure 7
Regulation of neuroinflammation by maternal LB supplementation in the two-week old offspring is mediated by transcriptional regulators. Transcripts of the IL-1β receptor Il1r1 (a) and the transcriptional regulators Cebpd (b) and Nfkbia (c) were evaluated by RT-PCR. Il1r1 gene expression was not affected by maternal LB supplementation (n = 5–6, (a). Cebpd (b) and Nfkbia (c) were upregulated by i.p. injection of IL-1β after four hours (n = 5-6). Maternal exposure of LB blocked the Il-1β-induced increased expression of these markers (n = 6–7). Data were normalized to Gapdh gene expression and are presented as mean ± SEM. Bars with ⎴ denote significant difference between experimental groups (at least p < 0.05).
