Table 2 Association of individual characteristics and unit policy of tocolysis after PPROM.

From: Unit policies regarding tocolysis after preterm premature rupture of membranes: association with latency, neonatal and 2-year outcomes (EPICE cohort)

Individual characteristics

Unit policy regarding the use of tocolysis after PPROM

p-value

No-use n = 101 (17 units)

Restricted n = 195 (32 units)

Liberal n = 311 (45 units)

Mother’s age (years) (n = 604)

   ≤20

7 (7.0)

16 (8.2)

13 (4.2)

0.19

   21–34

60 (60.0)

129 (66.5)

215 (69.3)

   ≥35

33 (33.0)

49 (25.3)

82 (26.5)

Mother born in Europe (n = 532)

60 (84.5)

127 (74.3)

240 (82.8)

0.054

Nulliparity (n = 605)

46 (45.5)

88 (45.1)

154 (49.8)

0.53

GA at PPROM (weeks) (n = 607)

   24

10 (9.9)

25 (12.8)

35 (11.3)

0.42

   25

14 (13.9)

25 (12.8)

57 (18.3)

   26

8 (7.9)

30 (15.4)

50 (16.1)

   27

15 (14.9)

29 (14.9)

43 (13.8)

   28

25 (24.7)

37 (19.0)

52 (16.7)

   29

29 (28.7)

49 (25.1)

74 (23.8)

In utero transfer (n = 599)

29 (29.6)

74 (38.1)

152 (49.5)

<0.001

Antenatal steroids (n = 594)

   None

1 (1.0)

6 (3.2)

7 (2.3)

0.20

   Uncomplete course

4 (4.0)

20 (10.7)

32 (10.4)

   Complete course

95 (95.0)

161 (86.1)

268 (87.3)

Magnesium sulfate (n = 563)

1 (1.0)

3 (1.7)

7 (2.4)

0.77

Spontaneous onset of labor (n = 602)

60 (59.4)

121 (62.7)

209 (67.9)

0.23

Induction of labor or cesarean before labor because of suspected infection (n = 163)

19 (63.3)

27 (60.0)

40 (45.5)

0.12

Latency duration (days) (n = 607)

   0.5–2

22 (21.8)

48 (24.6)

58 (18.6)

0.45

   3–7

38 (37.6)

69 (35.4)

126 (40.5)

   8–14

19 (18.8)

41 (21.0)

72 (23.2)

   15–21

10 (9.9)

17 (8.7)

35 (11.3)

   22–28

8 (7.9)

9 (4.6)

11 (3.5)

   >28

4 (4.0)

11 (5.7)

9 (2.9)

Mode of delivery (n = 596)

   Vaginal

49 (48.5)

78 (40.9)

136 (44.7)

0.37

   Cesarean before labor

32 (31.7)

61 (31.9)

82 (27.0)

   Cesarean during labor

20 (19.8)

52 (27.2)

86 (28.3)

GA at birth (weeks) (n = 607)

   24

3 (3.0)

11 (5.6)

11 (3.5)

0.31

   25

7 (6.9)

11 (5.6)

18 (5.8)

   26

6 (5.9)

19 (9.7)

48 (15.4)

   27

11 (10.9)

21 (10.8)

47 (15.1)

   28

22 (21.8)

38 (19.5)

48 (15.4)

   29

20 (19.8)

45 (23.1)

55 (17.7)

   30

21 (20.8)

35 (18.0)

58 (18.7)

   31

11 (10.9)

15 (7.7)

26 (8.4)

SGA ≤ 10th (n = 606)*

14 (13.9)

29 (15.0)

62 (19.9)

0.21

Male (n = 606)

61 (60.4)

99 (51.0)

179 (57.6)

0.22

  1. GA: gestational age, PPROM: preterm premature rupture of membranes, SGA: small for gestational age
  2. *According to intrauterine growth curves, based on weight in each country collected in the Euro-Peristat project and modeled using Gardosi’s formula.