Figure 1
From: Hyperpolarization of the subthalamic nucleus alleviates hyperkinetic movement disorders
Histological verification of animal models of hyperkinetic movement. (a) Tyrosine hydroxylase immunohistochemistry showing unilateral deprivation of dopaminergic innervation of the striatum (arrowheads) in a parkinsonian rat with levodopa-induced dyskinesia. (b) Bilateral striatal lesions (arrows) in a rat with hyperkinesia after direct intrastriatal 3-NP injection shown by cresyl violet staining. (c) Cresyl violet staining showing trajectories of the combined microinjection cannula/stimulation electrode in the bilateral subthalamic region in a levodopa-induced dyskinesia parkinsonian rat.
