Table 3 Logistic regression analysis of incidence of diarrhoea, by drug treatment, in CML patients.

From: Serotonin re-uptake transporter gene polymorphisms are associated with imatinib-induced diarrhoea in chronic myeloid leukaemia patients

Covariate

 

all patients

imatinib patients

dasatinib patients

r2

P value

OR (95% CI)

r2

P value

OR (95% CI)

r2

P value

OR (95% CI)

Drug

 

0.014

0.015

0.652 (0.462, 0.920)

—

—

—

—

—

—

Gender

 

0.021

0.002

0.585 (0.414, 0.826)

0.031

0.007

0.527 (0.331, 0.838)

0.009

0.174

0.694 (0.410, 1.174)

Age

 

0.009

0.049

1.012 (1.000, 1.024)

0.004

0.344

1.008 (0.992, 1.024)

0.016

0.077

1.016 (0.998, 1.033)

Age (≥ 65)

 

0.004

0.202

1.291 (0.872, 1.910)

0.003

0.436

1.234 (0.726, 2.098)

0.005

0.297

1.367 (0.760, 2.459)

BMI

 

0.011

0.034

1.035 (1.003, 1.069)

0.009

0.158

1.031 (0.988, 1.075)

0.009

0.176

1.035 (0.985, 1.088)

Platelets

 

0.000

0.997

1.000 (1.000, 1.000)

0.000

0.997

1.000 (0.999, 1.001)

0.000

0.955

1.000 (0.999, 1.001)

5-HTTLPR

biallelic

0.003

0.258

0.867 (0.676, 1.111)

0.023

0.021

0.666 (0.472, 0.940)

0.004

0.383

1.178 (0.815, 1.702)

rec

0.000

0.782

0.940 (0.605, 1.459)

0.000

0.997

1.001 (0.548, 1.828)

0.001

0.643

0.858 (0.448, 1.641)

dom

0.009

0.049

0.696 (0.486, 0.999)

0.052

0.0004

0.417 (0.255, 0.680)

0.004

0.358

1.304 (0.740, 2.299)

rs25531

biallelic

0.002

0.371

1.235 (0.777, 1.963)

0.001

0.587

1.195 (0.629, 2.270)

0.003

0.451

1.296 (0.660, 2.545)

5-HTTLPR + rs25531

biallelic

0.002

0.400

0.900 (0.704, 1.150)

0.024

0.020

0.663 (0.469, 0.937)

0.008

0.200

1.267 (0.882, 1.821)

rec

0.002

0.409

1.187 (0.790, 1.783)

0.007

0.221

1.429 (0.807, 2.528)

0.000

0.813

0.932 (0.519, 1.673)

dom

0.001

0.587

0.897 (0.606, 1.328)

0.027

0.012

0.509 (0.301, 0.862)

0.018

0.064

1.845 (0.965, 3.528)

STin2 VNTR

triallelic

0.002

0.366

1.074 (0.920, 1.255)

0.017

0.043

1.252 (1.007, 1.557)

0.003

0.470

0.917 (0.725, 1.160)

model B

0.002

0.364

1.100 (0.896, 1.351)

0.016

0.057

1.323 (0.992, 1.764)

0.002

0.513

0.902 (0.663, 1.228)

model A

0.001

0.477

1.092 (0.857, 1.390)

0.008

0.162

1.271 (0.908, 1.778)

0.001

0.666

0.924 (0.646, 1.322)

model A rec

0.002

0.348

0.803 (0.508, 1.270)

0.022

0.022

0.476 (0.252, 0.899)

0.004

0.373

1.389 (0.674, 2.864)

model A dom

0.000

0.746

1.059 (0.747, 1.503)

0.000

0.765

1.075 (0.670, 1.725)

0.000

0.961

1.013 (0.600, 1.712)

Covariate retained in model

 

r2

  

r2

     

Gender

 

0.023

  

—

     

Gender with BMI

 

0.034

  

—

     

5-HTTLPR dom

 

—

  

0.052

     

5-HTTLPR dom with gender

 

—

  

0.078

     
  1. Body mass index (BMI). Age, in years, as a continuous variable (Age). Age, in years, defined as under 65, or 65 and over, as a binary variable (Age ≥ 65). Serotonin-transporter-linked polymorphic region alone (5-HTTLPR); or combined with rs25531 SNP (5-HTTLPR + rs25531). Intron 2, 17 bp variable number of tandem repeats (STin2 VNTR); allelic model definitions described in Supplementary Table 2. Recessive allele (rec); dominant allele (dom). Text in bold indicates covariates included in the forward conditional regression model.
Back to article page