Table 4 Logistic regression analysis of incidence of diarrhoea, stratified by gender, in imatinib treated CML patients. Body mass index (BMI).

From: Serotonin re-uptake transporter gene polymorphisms are associated with imatinib-induced diarrhoea in chronic myeloid leukaemia patients

Covariate

 

male imatinib patients

female imatinib patients

r2

P value

OR (95% CI)

r2

P value

OR (95% CI)

Age

 

0.002

0.589

0.994 (0.973, 1.016)

0.055

0.022

1.032 (1.005, 1.060)

Age (≥ 65)

 

0.001

0.740

0.883 (0.424, 1.841)

0.030

0.084

2.091 (0.906, 4.827)

BMI

 

0.024

0.080

1.055 (0.994, 1.120)

0.000

0.926

1.003 (0.945, 1.064)

Platelets

 

0.007

0.355

0.999 (0.998, 1.001)

0.000

0.832

1.000 (0.999, 1.001)

5-HTTLPR

biallelic

0.029

0.053

0.610 (0.370, 1.007)

0.018

0.183

0.723 (0.448, 1.166)

rec

0.001

0.799

0.892 (0.369, 2.156)

0.000

0.992

0.996 (0.425, 2.331)

dom

0.049

0.010

2.420 (1.234, 4.744)

0.042

0.042

0.470 (0.227, 0.972)

rs25531

biallelic

0.010

0.245

1.638 (0.713, 3.766)

0.003

0.616

0.771 (0.279, 2.130)

5-HTTLPR + rs25531

biallelic

0.022

0.089

0.407 (0.407, 1.066)

0.028

0.099

0.652 (0.392, 1.084)

rec

0.010

0.271

0.631 (0.278, 1.433)

0.005

0.470

1.353 (0.595, 3.075)

dom

0.020

0.105

1.807 (0.884, 3.694)

0.038

0.053

0.449 (0.200, 1.009)

STin2 VNTR

triallelic

0.028

0.054

1.323 (0.996, 1.758)

0.009

0.338

1.185 (0.837, 1.678)

model B

0.034

0.035

1.510 (1.030, 2.212)

0.003

0.561

1.143 (0.729, 1.792)

model A

0.021

0.099

1.479 (0.929, 2.354)

0.001

0.761

1.081 (0.656, 1.781)

model A rec

0.017

0.129

1.933 (0.825, 4.532)

0.031

0.081

2.444 (0.895, 6.669)

model A dom

0.012

0.221

0.658 (0.337, 1.287)

0.007

0.394

1.357 (0.672, 2.742)

Covariate retained in model

r2

  

r2

  

5-HTTLPR dom

0.059

  

—

  

Age

—

  

0.055

  

Age with 5-HTTLPR + rs25531 dom

—

  

0.097

  
  1. Age, in years, as a continuous variable (Age). Age, in years, defined as under 65, or 65 and over, as a binary variable (Age ≥ 65). Serotonin-transporter-linked polymorphic region alone (5-HTTLPR); or combined with rs25531 SNP (5-HTTLPR + rs25531). Intron 2, 17 bp variable number of tandem repeats (STin2 VNTR); allelic model definitions described in Supplementary Table 2. Recessive allele (rec); dominant allele (dom). Text in bold indicates covariates included in the forward conditional regression model.
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