Table 1 Cytotoxicity (CC50), anti-ZIKV, or anti-CHIKV profile (EC50) and selectivity index (SI) of dolastane diterpenes.

From: In vitro Studies on The Inhibition of Replication of Zika and Chikungunya Viruses by Dolastane Isolated from Seaweed Canistrocarpus cervicornis

Compounds

 

ZIKV

CHIKV

CC50a(μg or μM)

EC50b(μg or μM)

SIc

EC50b(μg or μM) SIc

Extract

438 μg/mL ± 5.18

2.15 ± 0.22

203

2.45 ± 1.02

178

Dolastane

935 µM/mL ± 11.0

0.75 ± 0.18

1246

1.28 ± 0.47

730

Ribavirin

297 μM/mL ± 4.25

3.95 ± 0.95

75.2

2.42 ± 0.49

122

  1. The mean values ± standard deviations are representative of three independent experiments.
  2. aConcentration required to reduce 50% cell viability when compared to untreated controls.
  3. bConcentration that reduced 50% of ZIKV or CHIKV replication when compared to infected and untreated controls.
  4. cSelectivity index was defined as the ratio between CC50 and EC50.
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