Figure 3

Immune cell connectivity of meningiomas by location. A-B: Histogram of Person’s correlations for the top 3 cell fractions, ranked by connectivity, of convexity (A) and skull base (B) meningiomas. C: Difference between cell connectivity values, comparing convexity to skull base (“SB”), where positive values (blue) indicate greater connectivity in convexity while negative values (red) indicate greater connectivity in skull base meningiomas. D and E: Ranking of eigenvector centrality of each cell type for convexity (D) and skull base (E) tumours. F: Difference between eigenvector centrality, with the same conventions as (C). Note the highly connected mast cells and neutrophils in convexity meningiomas and T gamma-delta cells, monocytes, and plasma cells in skull base (“SB”) meningiomas. A = activated, M = mature, N = naïve, fh = follicular helper, gd = gamma-delta, R = resting.