Figure 1 | Scientific Reports

Figure 1

From: Of Mice and Monkeys: Neuroprotective Efficacy of the p38 Inhibitor BIRB 796 Depends on Model Duration in Experimental Glaucoma

Figure 1

Experimental timeline and schematic. (a) Experimental timelines for rat, mouse and squirrel monkey cohorts. Microbead injections (MOM injx, arrowheads), intravitreal injection of cholera toxin subunit B (CTB injx, perpendicular lines), baseline intraocular pressure measurements (IOPs, light gray bars) and treatment intraocular pressure measurements (IOPs, dark gray bars) were performed according to their position on the timelines. Treatment with vehicle or BIRB 796 is indicated by the bracketed line (|—|) and length of treatment (4 weeks, 24 weeks or 29 weeks). Scale: line indicates 1 week. (b) Experimental schematic for rat vehicle, BIRB-796, and naïve experimental groups showing which eyes received microbead or saline injection, which eyes received vehicle or BIRB 796 treatment, and which eyes received CTB injection. (c) Experimental schematic for DBA/2 J mouse vehicle and BIRB-796 experimental groups indicating eyes that received vehicle or BIRB 796 treatment, and eyes received CTB injection. (d) Experimental schematic for squirrel monkey (SM) vehicle and BIRB-796 experimental groups showing which eyes received microbead injection, which eyes received vehicle or BIRB 796 treatment, and which eyes received CTB injection.

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