Figure 1 | Scientific Reports

Figure 1

From: Soluble HLA-G expression levels and HLA-G/irinotecan association in metastatic colorectal cancer treated with irinotecan-based strategy

Figure 1

HLA-G and its main isoforms. (a) Crystal structure (PDB ID: 1YDP) of the extracellular HLA-G complex α1 (orange), α2 (yellow), and α3 (green colour) globular domains non-covalently associated with β2-microglobulin (pink colour) and antigen peptide (grey). (b) Exon 1 codifies for the 1–24 aa peptide signal that is lost in the mature protein (red), exon 2 generates the α1 domain, exon 3 the α2 domain (yellow), exon 4 the α3 domain. Exons 5 (light blue) and 6 for the transmembrane (TM) and cytoplasmic (CT) domains, respectively. (c) HLA-G mRNA transcripts and (d) resulting proteins.

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