Figure 5 | Scientific Reports

Figure 5

From: Soluble HLA-G expression levels and HLA-G/irinotecan association in metastatic colorectal cancer treated with irinotecan-based strategy

Figure 5

Representative conformation of each HLA-G polymorph and the docked CPT-11 for (a) HLA-G*01:01, (b) HLA-G*01:03, (c) HLA-G*01:04, (d) HLA-G*01:05 N. In all cases the S-S bridge forming Cys77 and Cys140 are highlighted. In (a–c) the mutated amino acids with respect to HLA-G*01:01 (at positions 31 and 110) are represented with their van der Waals spheres, and in (d) the substituted 60 aa peptide after Asp 129 is highlighted in a darker colour.

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