Figure 7 | Scientific Reports

Figure 7

From: Nuclear Parkin Activates the ERRα Transcriptional Program and Drives Widespread Changes in Gene Expression Following Hypoxia

Figure 7

Nuclear Parkin activates ERRα-regulated gene transcription. (a) Quantification of relative Luciferase activity in HeLa cells transfected with mCherry, Parkin, or NLS-Parkin plus ERE/ERRE-Luciferase reporter (n = 3). (a) Real-time quantitative PCR of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha (PPARGC1α), Hexokinase 1 (HK1), Acyl-CoA Dehydrogenase Medium chain (ACADM), Acyl-CoA Dehydrogenase Very Long chain (ACADVL), Estrogen Related Receptor alpha (ESRRA), Peroxisome Proliferator-Activated Receptor alpha (PPARα), Fatty Acid Binding Protein 3 (FABP3), and High Mobility Group Box 2 (HMGB2) in HeLa cells expressing mCherry, Parkin, or NLS-Parkin (n = 3–6). *p < 0.05, ***p < 0.001 compared to mCherry.

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