Table 1 Genotype and allele analysis of 34 SNPs among 221 individuals with PD.

From: Substantia nigra echogenicity is associated with serum ferritin, gender and iron-related genes in Parkinson’s disease

 

Total (n = 221)

SN+ (n = 122)

SN− (n = 99)

OR

95% CI

P

Gender (Male, %)

138 (62.4%)

92 (75.4%)

46 (46.5%)

0.32

0.16–0.63

0.001*

Age (years)

62.5 ± 8.6

63.4 ± 8.2

61.4 ± 9.0

1.02

0.98–1.06

0.260*

PD Duration (years)

4.3 ± 3.6

4.3 ± 3.8

4.2 ± 3.2

1.01

0.91–1.13

0.833*

H-Y

2.1 ± 0.7

2.1 ± 0.7

2.1 ± 0.8

0.78

0.42–1.46

0.432*

UPDRS-III

25.0 ± 11.9

25.6 ± 12.7

24.4 ± 10.9

1.01

0.97–1.05

0.552*

rs731821 (CC/CA/AA)

122/87/12

75/44/3

47/43/9

0.45

0.24–0.86

0.016*

rs3737084 (CC/CG/GG)

132/74/15

62/49/11

70/25/4

2.07

1.17–3.67

0.013*

Gender (Male, %)

276 (62.4%)

184 (75.4%)

92 (46.5%)

0.31

0.20–0.49

<0.001†

Age (years)

62.5 ± 8.6

63.4 ± 8.2

61.4 ± 9.0

1.02

0.99–1.05

0.139†

PD Duration (years)

4.3 ± 3.5

4.3 ± 3.8

4.2 ± 3.2

1.01

0.94–1.09

0.791†

H-Y

2.1 ± 0.7

2.1 ± 0.7

2.1 ± 0.7

0.79

0.53–1.19

0.264†

UPDRS-III

25.0 ± 11.9

25.6 ± 12.7

24.4 ± 10.9

1.01

0.99–1.04

0.293†

rs731821 (C/A)

331/111

194/50

137/61

0.44

0.24–0.83

0.011†

rs3737084 (C/G)

338/104

173/71

165/33

2.51

1.39–4.53

0.002†

  1. PD: Parkinson’s disease; SN+: Substantia nigra hyperechogenicity; SN−: Substantia nigra hypoechogenicity; OR: odds ratio; H-Y: Hoehn and Yahr stage (“off” state); UPDRS-III: Unified Parkinson Disease Rating Scale Part III (“on” state).
  2. *P-values estimated from binary logistic regression models adjusted for age, gender, disease severity, and disease duration. The results of the other 32 SNPs are available in Supplemental Table 2.
  3. †P-values estimated from binary logistic regression models adjusted for age, gender, disease severity, and disease duration. The results of the other 32 SNPs are available in Supplemental Table 3.
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