Figure 1

Model diagram. The model is composed of two compartments: prostate gland and lymphoid tissue. Cells are represented in orange squared boxes, while molecules in green rounded ones. In the prostate gland compartment the cancer is in its two forms: Androgen Dependent Prostate Cancer (ADPC) and Androgen Independent Prostate Cancer (AIPC). Other players involved: mature Dendritic cell (Dm), regulatory T cell (Treg), Myeloid-Derived Suppressor Cell (MDSC), Cytotoxic T Lymphocyte (CTL), Natural Killer cell (NK), functional Dendritic cells (Df), regulatory Dendritic cells (Dr), Androgen (A) and Interleukin-2 (IL-2). Double arrows represent transformations, single lines represent promotions and inhibitions, while dashed lines depict the seven implemented treatments. A complete description of the treatments and the corresponding abbreviations are reported in Table 1.