Figure 6

Treatment decision tree. Limiting the tree to androgen deprivation as root node, therapies have been step-wise combined to synergise (BCI reported on the corresponding edge). Each node position has been computed according to the relative tumor change after 4 weeks (scale on the right). Combined therapies at the bottom are the most effective on the tumor size. The scale thickness emphasizes the nodes able to decrease the tumor size with respect to (w.r.t.) the baseline. For simplicity, branches showing the same pattern have been replaced by stars indicating the branch of reference (\({\ast }^{1}\) = CX + V + AM, \({\ast }^{2}\) = CX + V + ICB, \({\ast }^{3}\) = CX + AM + ICB). Treatments are named by the following abbreviations: Androgen Deprivation (CX), Anti-IL-2 (AI), Anti-Treg (AR), Anti-MDSC (AM), Vaccine (V), injection of NK cells (NK) and Immune-Checkpoint Blockade (ICB).