Figure 6 | Scientific Reports

Figure 6

From: Extracellular vesicles from genetically unstable, oncogene-driven cancer cells trigger micronuclei formation in endothelial cells

Figure 6

Uptake of EVs from RAS-driven cancer cells triggers features of genetic instability in endothelial cells. (A) Untreated HUVEC. (B) HUVEC treated with etoposide. (C) HUVEC treated with IEC-18 EVs. (D) HUVEC treated with RAS-3 EVs (DAPI – blue; anti-phospho-histone γH2AX – green). (E) Quantification of endothelial micronuclei with and without γH2AX staining. (F) Endothelial micronuclei with and without γH2AX staining (high magnification – 1,000×); **p < 0.01.

Back to article page