Figure 7 | Scientific Reports

Figure 7

From: Extracellular vesicles from genetically unstable, oncogene-driven cancer cells trigger micronuclei formation in endothelial cells

Figure 7

Induction of micronuclei in endothelial cells exposed to EVs from oncogene-driven cancer cells. HUVEC cells were exposed for 7 days to EVs from cancer cells expressing mutant HRAS (carcinoma) or EGFRvIII (glioblastoma). (A) HUVEC micronuclei count upon treatment with control, IEC-18- or RAS-3-derived EVs. (B) HUVEC micronuclei count upon treatment with control, U373P- or U373vIII-derived EVs; **p < 0.01; ***p < 0.0001.

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