Figure 3 | Scientific Reports

Figure 3

From: Lentiviral mediated RPE65 gene transfer in healthy hiPSCs-derived retinal pigment epithelial cells markedly increased RPE65 mRNA, but modestly protein level

Figure 3

iRPE cells present characteristic ultrastructure features of human adult RPE (a) Typical iRPE cell ultrastructure with a large nucleus in the basal part of the cell and with dense structures in the apical region containing microvilli. (c–e) Inserts show these iRPE cell features with high magnification. (b,c) Tight junctions (arrows) between two iRPE cells. (d) Multiple apical microvilli (AMv) are present at the cell surface. (e) Melanosomes (arrowheads) at different maturation stages were observed. Nu, Nucleus; Ph, Phagosome; M, Mitochondria.

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