Table 1 Characteristics of the included studies.

Cancer	First author	Year	Country	Sample type	Sample size(n)	Detection method	Cut-off value	PT	Survival analysis	Multivariate analysis	Hazard ratios	NOS score
GC	Wei Zhang⁹	2018	China	Tissue	76	qRT-PCR	NA	no	OS	No	K-M curve	7
GC	Yufeng Wang¹⁶	2018	China	Tissue	64	qRT-PCR	NA	NA	OS, DFS	No	K-M curve	6
GC	Jianjun Peng¹⁷	2018	China	Tissue	58	qRT-PCR	mean	no	OS	Yes	K-M curve	6
GC	Zhi Ding¹⁸	2018	China	Tissue	72	qRT-PCR	median	no	OS	no	K-M curve	6
Breast cancer	Qiongyan Zou¹⁹	2017	China	Tissue	86	qRT-PCR	median	NA	NA	No	NA	8
Breast cancer	Jia Yao¹³	2017	China	Tissue	36	qRT-PCR	2-fold	NA	OS	Yes	Text	7
Ovarian cancer	Xiaoqian Wang²⁰	2018	China	Tissue	60	qRT-PCR	median	NA	NA	No	NA	8
Ovarian cancer	Xiuyun Li³⁴	2018	China	Tissue	62	qRT-PCR	mean	no	OS	Yes	K-M curve	6
Osteosarcoma	Xi Chen³⁵	2018	China	Tissue	132	qRT-PCR	NA	no	OS	Yes	Text	7
Osteosarcoma	Guangling Yang¹²	2018	China	Tissue	46	qRT-PCR	mean	no	OS	No	K-M curve	8
Brain glioma	Rong Zhang²³	2017	China	Tissue	47	qRT-PCR	median	NA	OS	Yes	Text	7
HCC	Shaling Li¹¹	2017	China	Tissue	84	qRT-PCR	median	NA	OS	no	K-M curve	8
Pancreatic cancer	Xianping Cui²⁴	2019	China	Tissue	77	qRT-PCR	NA	NA	OS	No	K-M curve	7
LAD	Chunfeng Liu²⁵	2019	China	Tissue	80	qRT-PCR	median	no	OS	Yes	K-M curve	7
NSCLC	Lin Zhang¹⁹	2018	China	Tissue	45	qRT-PCR	median	NA	OS	No	K-M curve	7
Bladder cancer	Zhiyong Tuo¹⁰	2018	China	Tissue	128	qRT-PCR	median	no	OS, PFS	No	K-M curve	7
ccRCC	Guanghua Liu²⁶	2018	China	Tissue	40	qRT-PCR	median	no	OS, DFS	No	K-M curve	8
CCA	Yue Yao¹³	2018	China	Tissue	75	qRT-PCR	mean	no	NA	No	NA	8
CRC	Zeming Jia²⁷	2019	China	Tissue	61	qRT-PCR	NA	no	NA	No	NA	7

Abbreviations: GC, gastric cancer; HCC, hepatocellular carcinoma; LAD, lung adenocarcinoma; NSCLC, non-small cell lung cancer; ccRCC, clear cell renal cell carcinoma; CCA, cholangiocarcinoma; CRC, colorectal cancer; PT, preoperative treatment; NA, Not available.

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