Figure 4 | Scientific Reports

Figure 4

From: Spatio-temporal patterning of different connexins in developing and postnatal human kidneys and in nephrotic syndrome of the Finnish type (CNF)

Figure 4

Co-expression of synaptopodin and nephrin with different Cx in developing and CNF kidneys. (a-d,e–h) Human kidneys in the 22nd developmental week. (i–l,m–p) Postnatal CNF kidneys. Cx43and Cx43 expression (arrows), synaptopodin and nephrin expression (arrows), glomeruli (g), proximal (pt) and distal tubules (dt), juxtaglomerular region (jga). DAPI nuclear staining (c,g,k,o). Merged view of Cx43 or Cx45 with synaptopodin shows co-expression of the two markers (arrowheads) in the glomeruli (podocytes) of healthy kidneys (d,h), and absence of their co-expression in CNF kidneys (l,p). Double immunofluorescence staining of DAPI with Cx43 or Cx45 with nephrin or synaptopodin x100.

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