Figure 5 | Scientific Reports

Figure 5

From: Spatio-temporal patterning of different connexins in developing and postnatal human kidneys and in nephrotic syndrome of the Finnish type (CNF)

Figure 5

Co-expression of different Cxs with markers of proximal tubules (DBA) and distal tubules (LTL) in developing, postnatal and CNF kidneys. (a–d) Human kidneys in the 10th developmental week. (e–h,i–l) Human postnatal kidneys (1,5 years). (m–p) Postnatal CNF kidneys (3,5 years). Cx37, Cx40 and Cx45 expression (arrows), expression of markers for proximal (DBA) and distal (LTL) tubules (arrows), proximal tubules (pt), distal tubules (dt), collecting tubules (ct), interstitium (i), glomeruli (g), blood vessels (bv). Co-expression of Cx37 with LTL is missing in 10th developmental week kidneys (a–d), while co-expression of Cx40/DBA (arrowhead) (e–h) and Cx43/LTL (arrowhead) (i–l) is seen in proximal and distal tubules of postnatal kidneys. In CNF, Cx37 co-expresses with DBA (arrowhead) in dilated proximal tubules. Double immunofluorescence staining of DAPI with Cx37/LTL, Cx40/DBA, Cx43/LTL and Cx37/DBA x40.

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