Figure 5 | Scientific Reports

Figure 5

From: Activation of cortical M1 muscarinic receptors and related intracellular signaling is necessary for reactivation-induced object memory updating

Figure 5

M1 mAChR activation within PRh is necessary for object memory updating in the PROMM task. (a) Intra-PRh microinjections (blue arrow) of the M1 mAChR antagonist pirenzepine or its vehicle were administered immediately prior to object memory reactivation in the Y-apparatus (n = 10). (b) Object exploration in the vehicle/same alternate context condition was lower than object exploration in the pirenzepine/same alternate context condition, vehicle/different alternate context condition, and pirenzepine/different alternate context condition. **p < 0.01, ***p < 0.001.

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