Figure 7 | Scientific Reports

Figure 7

From: Activation of cortical M1 muscarinic receptors and related intracellular signaling is necessary for reactivation-induced object memory updating

Figure 7

Activation of intracellular IP3 receptors is required for reactivation-based memory updating in the PROMM task. (a) Microinjections (blue arrow) of the IP3 receptor antagonist XeC or its vehicle were administered into PRh 20 min before memory reactivation in the Y-apparatus (n = 11). (b) Rats administered pre-reactivation XeC displayed greater exploration in the same alternate context condition compared to rats in the vehicle/same alternate context condition. Rats in the different alternate context condition displayed greater object exploration than the vehicle/same alternate context condition, regardless of drug. *p < 0.05.

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