Figure 1
From: A heritable profile of six miRNAs in autistic patients and mouse models
Decreased expression of the six-miRNAs miR-3613-3p, miR-150-5p, miR-126-3p, miR-361-5p, miR-19a-3p, and miR-499a-5p in children with autism and their fathers and mothers compared to age- and sex-matched healthy controls. In the cohort of patients with autism assembled in Kayseri, Turkey, we performed qRT-PCR as described in the Methods to analyze the microRNA profiles of serum samples from 45 autistic children (2–13 years old, 31 boys and 14 girls), their 33 siblings (1–20 years old, 17 boys and 16 girls), their 74 parents (mothers 23–45 years old, fathers 24–51 years old) and 21 control age-matched healthy children (3–16 years old, 10 boys and 11 girls) and their 16 parents, for a total of 189 participants. The expression levels of six-miRNAs miR-3613-3p (A), miR-150-5p (B), miR-126-3p (C), miR-361-5p (D), miR-19a-3p (E), and miR-499a-5p (F) showed statistically significant differences (p < 0.05). The six-miRNA-transcript profiles graphed for a multiplex family (with more than one child with autism), and the tables below show the log fold-change rates for children with autism to control children (G, H) and their mothers (I,J) and fathers to father control (K,L) compared to age- and sex-matched healthy controls (p < 0.0001). Heatmap shows the fold-change variation according to color (M), and in the figure, the columns represent the groups, and the rows represent the miRNAs (red, black and green correspond to upregulated, unchanged and downregulated, respectively). N. shows 6 miRNA expression profile in multiplex (more than one child with autism, n = 9) and simplex (one child with autism, n = 28) families.
