Figure 5
The effects of dipentylammonium and triisopentylammonium on serotonin, dopamine and norepinepherine reuptake. (a) fluoxetine (open squares) dose-dependently prevents serotonin reuptake (IC50 83 nM), whereas dipentylammonium (open circles) and triisopentylammonium (closed squares) required a far higher concentration to prevent any serotonin uptake (IC50 1.1 mM and IC50 7.8 mM respectively). (b) GBR-12935 (open squares) inhibited dopamine transport with IC50 of 76 nM whereas dipentylammonium (open circles) and triisopentylammonium (closed squares) required a far higher concentration to prevent any dopamine uptake (IC50 0.6 mM and IC50 1.6 mM respectively). (c) Desipramine (open squares), potently inhibited norepinepherine (NE) reuptake with IC50 9 nM, whereas dipentylammonium (open circles) and triisopentylammonium (closed squares) required a far higher concentration to prevent any norepinepherine uptake (IC50 0.2 mM and IC50 7.8 mM respectively).
