Figure 2

Overall structure of PcUP1. (a) PcUP1 Dimer. The dimer is presented as a cartoon model with α-helices colored marine, β-strands colored light pink and loops colored white. The active pocket is marked in a red circle.In the circle, glycerol is shown as stick and active residues of the interaction network is shown as lines. (b) PcUP1 monomer. The monomer is presented as a cartoon model with α-helices colored marine, β-strands colored light pink and loops colored white with the UP-specificity region green and the hexamer-blocking inserts cyan. (c) Electrostatic surface presentation of native PcUP1 monomer structure. Glycerol is shown as stick and active residues of the interaction network is shown as lines. (d) The larger features are also labeled on the right. His19 and Arg59, marked with an asterisk, are contributed by the neighboring monomer.