Figure 2

High circulating FN-EDA in one-week HFD fed IR mice. (A) Bar diagram represents the circulating level of FN-EDA in male mice blood plasma following HFD feeding for one-week. HFD feeding for one-week significant increase FN-EDA in male mice. (B) Bar diagram depicts FPG in one-week HFD fed male mice. Glucometer was used to measure blood glucose in 6 hours fasted male mice. HFD feeding for one-week significant increases FPG in male mice compared to chow-fed mice. Line and bar graph represent glucose disposal following (C and D) IPGTT and (E and F) IPITT in male mice kept on HFD for one-week. Blood samples were collected from the tail vein at various time points starting from time zero to until 90 minutes following glucose and insulin infusion. Glucose disposal was significantly impaired overtime in HFD fed mice following glucose and insulin tolerance tests. Data represented as mean (SD) and P < 0.05 considered statistically significant.