Figure 1
From: miR-379 links glucocorticoid treatment with mitochondrial response in Duchenne muscular dystrophy
GRMD cohort and miRNA expression. 1a. Phenotype variations through ages of GRMD dogs. 1b. Fold change of normalized mRNA abundance in muscle biopsies of 2-month old dogs (n = 9–10). CD11b: CD11 Antigen-Like Family Member, Col6a: collagen 6a3; MYH8: myosin heavy chain 8; BF: Biceps Femoris; SC: Sartorius Cranialis. 1c. Heat map classification of miRNA dysregulation in GRMD muscle biopsies, Biceps Femoris (BF) and Sartorius Cranialis (SC) moderate and severe phenotypes. The myomiRs and miRNAs from the Dlk1-Dio3 locus are marked by black arrows. 1d. Principal component analysis of muscle (combined SC and BF) miRNA expression in dog groups, wild type (WT), GRMD severe (SEV), and GRMD moderate (MOD). 1e. Principal component analysis of miRNA expression in GRMD muscles (combined moderate and severe group) Sartorius cranialis (SC) and biceps femoral (BF). Circles mark the aggregation of the individuals according to their group. Small circles denoted 95% confident interval of the gravity center, while the larger discontinued-line circles surrounds 95% of the dots.
