Table 1 IC50 values of AZD1775 in TNBC cells.

From: Antitumor effect of a WEE1 inhibitor and potentiation of olaparib sensitivity by DNA damage response modulation in triple-negative breast cancer

Cell lines

TP53 mutation status

IC50 of AZD1775 (μmol/L)

MDA-MB-157

Mutant

0.5529

MDA-MB-231

Mutant

0.3550 ± 0.01

MDA-MB-468

Mutant

0.8151

HCC1143

Mutant

0.4538 ± 0.07

BT-549

Mutant

0.3381 ± 0.01

Hs 578 T

Mutant

0.7884

  1. The TP53 mutation appeared in our TNBC cells, and the cells showed various IC50 values in response to the AZD1775 treatment, even when the TP53 mutation was present. IC50 values were calculated using SigmaPlot.
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