Figure 4
From: Expression and prognostic value of the transcription factors EGR1 and EGR3 in gliomas
MGMT-methylation distribution and multivariate cox-regression for EGR1/EGR3 combinations. (A) The distribution of MGMT-methylation status was highly skewed when looking at the two EGR1 groups: The majority of patients in the EGR1 high group had a methylated MGMT-promoter, while 100% of patients in the EGR1 low group had un-methylated MGMT-promoters. (B) TCGA mRNA data showed a significant inverse correlation between EGR1 and MGMT mRNA levels. (C) TCGA data showed that patients with recurrent GBM and high EGR3 mRNA levels had significantly shorter survival compared to patients with low EGR3 mRNA levels. (D,E) Multivariate Cox-regression of the different EGR1 and EGR3 combinations showed that patients with EGR1 high/EGR3 high had a worse prognosis than patients with EGR1 high/EGR3 low. * = P < 0.05. ** = P < 0.01. *** = P < 0.001.
