Table 2 Comparison of the hydrogen bond interdomain protein-protein interactions of GTP- and cGMP-bound cyclase complexes.
From: Probing the Structural Dynamics of the Catalytic Domain of Human Soluble Guanylate Cyclase
Complexes | Acceptor | Donor | Percent Occupancy | Average Distance | Average Angle |
|---|---|---|---|---|---|
Cyclase-GTP | α:E526@O β:E473@O β:D458@O β:N451@O β:V532@O | β:R539@N α:R593@N α:K590@N α:G588@N α:N507@N | 87.22 74.77 53.40 43.01 27.74 | 2.80 2.82 2.90 2.90 2.88 | 158.35 158.39 165.89 154.60 161.13 |
Cyclase-cGMP | α:D514@O β:M537@O β:P538@O α:N507@O α:R593@O α:T527@O β:N431@O β:V532@O α:E526@O | β:Q535@N α:T527@O α:R593@N β:G534@N β:G476@N β:R539@N α:T602@O α:N507@N β:R539@N | 81.62 80.29 56.53 51.60 35.17 30.07 25.37 25.37 23.88 | 2.83 2.74 2.81 2.86 2.88 2.83 2.75 2.87 2.79 | 159.18 162.54 152.30 153.87 153.52 150.91 162.06 164.44 155.82 |
