Table 2 HPV-driven OPC cases: anatomo-clinical differences by viral type. HPVno16+ cases = HPV types 33 (3 cases), 18 and 58 (1 case each).

From: Age-independent increasing prevalence of Human Papillomavirus-driven oropharyngeal carcinomas in North-East Italy

 

HPV16 + 

N = 37

HPVno16+

N = 5

Fisher exact test

Gender

Female

16

2

p = 1.000

Male

21

3

 

M/F ratio

1,3

1,5

 

Age (years)

Median

62

78

p = 0.004a

Range

41–83

69–84

 

Year of diagnosis

2000–2006

6 (100%)

0 (0%)

p = 0.672

2007–2012

11 (92%)

1 (8%)

 

2013–2018

20 (83%)

4 (17%)

 

Cancer subsite

Tonsil

28 (76%)

3 (60%)

p = 0.131

Base of tongue

9

2

 

TNM stage (8th ed.)

I-II

23 (62%)

4 (80%)

p = 0.639

III-IV

14

1

 

Tobacco smoking

Never

17 (46%)

1 (20%)

p = 0.501

Alcohol drinking

Never

26 (70%)

4 (80%)

p = 1.000

Clinical outcome

Complete remission

34 (92%)

5 (100%)

 

OS status: 1

8

0

 

PFS status: 1

9

0

 

Exitus: 1

8

0

 
  1. aWilcoxon test.
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