Figure 4 | Scientific Reports

Figure 4

From: Acellular bioscaffolds redirect cardiac fibroblasts and promote functional tissue repair in rodents and humans with myocardial injury

Figure 4

Intact Bioscaffolds Improve Post-MI Functional Recovery. (A) Left ventricular ejection fraction is shown from hearts without a bioscaffold (N = 15), neutralized bioscaffolds (N = 16), or intact bioscaffolds (N = 16) as measured by serial echocardiography at 2-weeks (baseline) and 14-weeks after myocardial infarction. We randomized animals to group at 3 weeks after myocardial infarction. We calculated statistical significance using repeated measures two-way ANOVA. We observed group differences for ejection fraction by time (P = 0.007), treatment (P = 0.04), and interaction (P = 0.001). Values are reported as mean ± SD. We performed load-insensitive assessments of cardiac performance using pressure-volume loop analysis. End-systolic pressure volume relationship (ESPVR; B) and preload-recruitable stroke work (PRSW; C) is reported in animals without scaffolds (N = 15), neutralized scaffolds (N = 17) or intact scaffolds (N = 13). We calculated statistical significance using one-way analysis of variance (ANOVA). Box plots represent median, and interquartile range. Whiskers represent maximum and minimum values.

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