Figure 1

Immediate biodistribution. (A) First planar view scintigraphic images acquired 1 hour after intra-arterial injection of either (from left to right) ¹¹¹In-oxine, ¹¹¹In-oxine-labelled leukocytes, myoblasts, or MABs in WT or GRMD dogs. (B) The mean proportion of the whole-body radioactivity measured in each ROI on images obtained 1 hour after injection, and for each cell type, is represented as cumulative histograms. The proportion of radioactivity trapped in the injected limb (black) is higher in animals injected with myogenic stem cells (Myoblasts or MABs) and reached the maximal value for MAB-transplanted GRMD dogs. Filter organs (pale grey) trapped a higher proportion of radioactivity in the case of ¹¹¹In-oxine and ¹¹¹In-oxine-labelled leukocytes. (C) Individual values of radioactivity measured in the injected limb relative to the whole body for myogenic stem cells. Radioactivity was trapped more efficiently in the injected limbs of MAB-transplanted GRMD dogs, with the exception of one dog that showed relative radioactivity levels that overlapped those observed in WT dogs. The relative radioactivity in the injected limb of myoblast-transplanted GRMD dogs was lower than in MAB-transplanted GRMD dogs, suggesting the trapping of myoblasts in the injected limb in less efficient than for MABs.