Figure 3
Nuclear and cytoplasmic distribution of mRNAs coding for secretases (Adam9, Adam10, Adam17, and Bace1) mRNAs. Using the m6A-Seq dataset generated by Hsu and colleagues (Hsu Supplementary Table 5 18), RPKM values were extracted for nuclear and cytoplasmic fractions isolated from cortices of WT and Fmr1KO mice (postnatal day 11) and the mean expression level was plotted as response variable versus mouse genotype as predictor. Error bars represent standard error of the mean (SEM). Asterisks indicate statistical differences between nuclear and cytoplasmic compartments computed by 2-way ANOVA with post-hoc Bonferroni multiple comparison tests (p < 0.050).
