Figure 4
Potential function of FMRP in regulating the transport of Adam9 and Psen1 mRNA into the cytoplasm. (A) Under normal conditions, FMRP recognizes m6A sites on multiple mRNAs, including Adam9 and Psen1, and interacts with the mRNA transport machinery (not shown). Transported mRNAs are available for protein synthesis resulting in normal levels of ADAM9 and PSEN1 protein and normal APP processing. (B) The absence of FMRP leads to reduced transport of m6A-marked mRNAs, potentially reducing levels of ADAM9 and PSEN1 proteins. While ADAM10 activity may compensate, disruption of the gamma-secretase complex may result in subtle cell dysfunction.
