Figure 4
The expression of psoriasis-related cytokines in the lesional skin of control skin, IMQ-induced psoriasiform dermatitis, and IMQ-induced psoriasiform dermatitis treated with ambrisentan. RNA was obtained from the ear skin of control mice, IMQ-treated mice, and IMQ+ ambrisentan or bosentan-treated mice at day 4 (a,c) or day 6 (b,d). mRNA levels of TNF-α, IL-12 p40, IL-23 p19, and IL-17 were determined by quantitative PCR. Results are representative of similar results obtained in three independent experiments. Data are presented as mean ± SEM (n = 4 for each group). *P < 0.05, **P < 0.01 versus IMQ-treated group.
