Table 5 Cox multivariable analysis of patients and treatment variables associated with overall survival and recurrence free survival (n = 454).

From: Improved survival after treatments of patients with nonalcoholic fatty liver disease associated hepatocellular carcinoma

Variable

HR

95% CI

P value

Overall Survival

Male gender

0.16

0.88–1.54

0.2891

Age (per year)

0.99

0.98–1.01

0.0741

Etiologies:

HCV vs HBV

0.96

0.68–1.34

0.8118

NAFLD vs HBV

0.35

0.15–0.80

0.0134

NAFLD vs HCV

0.37

0.17–0.77

0.0034

Race/Ethnicity

African American

Ref

White

0.66

0.23–1.89

0.4379

Asian

0.74

0.26–2.05

0.5568

Hispanic

0.9

0.30–2.68

0.8478

Not Hispanic

1.52

0.39–5.86

0.5451

Most definitive treatment:

Chemotherapy

Ref

OLT (after year 2000)

0.08

0.04–0.17

<0.0001

OLT (before year 2000)

0.11

0.04–0.27

<0.0001

PEI

0.36

0.14–0.92

0.0338

Resection

0.15

0.08–0.29

<0.0001

RFA

0.16

0.08–0.30

<0.0001

TACE

0.45

0.26–0.79

0.0055

Supportive care

0.83

0.49–1.42

0.5

Recurrence Free Survival

Male gender

1.12

0.90–1.51

0.245

Age (per year)

0.99

0.98–1.01

0.0626

Etiologies:

   

HCV vs HBV

1.08

0.78–1.49

0.6504

NAFLD vs HBV

0.69

0.39–1.39

0.3002

NAFLD vs HCV

0.64

0.34–1.20

0.163

Ethnicity:

African American

Ref

White

0.76

0.27–2.18

0.6104

Asian

0.91

0.33–2.53

8608

Hispanic

0.92

0.31–2.71

0.8734

Not Hispanic

0.84

0.24–2.93

0.7824

Most definitive treatment:

Chemotherapy

Ref

OLT (after year 2000)

0.09

0.05–0.17

<0.0001

OLT (before year 2000)

0.11

0.04–0.28

<0.0001

PEI

0.38

0.15–0.98

0.0461

Resection

0.24

0.14–0.44

<0.0001

RFA

0.28

0.16–0.51

<0.0001

TACE

0.54

0.31–0.93

0.0276

Supportive Care

0.75

0.43–1.26

0.2749

  1. Harrell’s C-statistic =0.780 for the overall survival and 0.737 for the recurrence-free survival.