Table 3 Simulated pharmacokinetic parameters of dabigatran following multiple administrations of 150 mg twice-daily dabigatran etexilate alone or with multiple dose of ticagrelor at 90 mg twice daily.

From: Predicted effect of ticagrelor on the pharmacokinetics of dabigatran etexilate using physiologically based pharmacokinetic modeling

 

Cmax (μg/mL)

Tmax (h)

AUC0-t (μg·h/mL)

AUC0-inf (μg·h/mL)

Ticagrelor-baseline/DDI

13.48

123.4

1190000

98300000

Dabigatran-baseline

0.138

121.3

8334.9

8452.9

Dabigatran-DDI

0.15

121.3

8925.4

9073.3

Dabigatran-ratio

1.087

1

1.071

1.073

  1. Cmax, maximum plasma concentration; Tmax, time from last dosing to the maximum plasma concentration; AUC0-inf, area under the concentration-time curve over the simulated period; AUC0-t, area under the concentration-time curve till infinite; DDI, drug-drug interaction.
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