Table 4 Simulated pharmacokinetic parameters of dabigatran following multiple administrations of a single 150 mg dose dabigatran etexilate alone or with a fore-4-dose (4 days) ticagrelor at 400 mg.

From: Predicted effect of ticagrelor on the pharmacokinetics of dabigatran etexilate using physiologically based pharmacokinetic modeling

 

Cmax (μg/mL)

Tmax (h)

AUC0-t (μg·h/mL)

AUC0-inf (μg·h/mL)

Ticagrelor-baseline/DDI

24.2

106

1700000

16100000

Dabigatran-baseline

0.109

97.7

693.4

768.2

Dabigatran-DDI

0.123

97.8

823.7

931

Dabigatran-ratio

1.128

1.001

1.188

1.212

  1. Cmax, maximum plasma concentration; Tmax, time from last dosing to the maximum plasma concentration; AUC0-inf, area under the concentration-time curve over the simulated period; AUC0-t, area under the concentration-time curve till infinite; DDI, drug-drug interaction.
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